Representative original research articles (2012 – present):
KCTD13 is a major driver of mirrored neurodevelopmental phenotypes associated with the 16p11.2 CNV in humans.
Golzio C, Willer J, Talkowski ME, Oh EC, Taniguchi Y, Jacquemont S, Reymond A, Sun M, Sawa A,
Gusella JF, Kamiya A, Beckmann JS, Katsanis N
Nature. 2012; 485:363-7.
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.
Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S-I, Ozaki N, Nabeshima T, Sawa A
Science. 2013; 339:335-9.
Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness.
Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, Emiliani F, Sawa A, Gallagher M
Proc Natl Acad Sci USA. 2013; 110:12462-7.
Disruptive CHD8 mutations define a subtype of autism early in development.
Bernier R, Golzio C, Xiong B, Stessman HA, Coe BP, Penn O, Witherspoon K, Gerdts J, Baker C, Vulto-van Silfhout AT, Schuurs-Hoeijmakers JH, Fichera M, Bosco P, Buono S, Alberti A, Failla P, Peeters H, Steyaert J, Vissers LE, Francescatto L, Mefford HC, Rosenfeld JA, Bakken T, O'Roak BJ, Pawlus M, Moon R, Shendure J, Amaral DG, Lein E, Rankin J, Romano C, de Vries BB, Katsanis N, Eichler EE.
Cell. 2014; 158:263-76.
Maternal complement C1q and increased odds for psychosis in adult offspring.
Severance EG, Gressitt KL, Buka SL, Cannon TD, Yolken RH.
Schizophr Res. 2014; 159:14-9.
Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling.
Liu Y, Pham X, Zhang L, Chen PL, Burzynski G, McGaughey DM, He S, McGrath JA, Wolyniec P, Fallin MD, Pierce MS, McCallion AS, Pulver AE, Avramopoulos D, Valle D.
G3 (Bethesda). 2014; 5:61-72.
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.
Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A.
Mol Psychiatry. 2016; 21:1449-59.
The DPYSL2 gene connects mTOR and schizophrenia.
Pham X, Song G, Lao S, Goff L, Zhu H, Valle D, Avramopoulos D.
Transl Psychiatry. 2016; 6:e933.
Cerebral complement C1q activation in chronic Toxoplasma infection.
Xiao J, Li Y, Gressitt KL, He H, Kannan G, Schultz TL, Svezhova N, Carruthers VB, Pletnikov MV, Yolken RH, Severance EG.
Brain Behav Immun. 2016; 58:52-56.
Developmental alcohol exposure impairs activity-dependent S- Nitrosylation of NDEL1 for neuronal maturation.
Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A.
Cereb Cortex. 2017; 3918-29.
DISC1 in astrocytes influences adult neurogenesis and hippocampus-dependent behaviors in mice.
Terrillion CE, Abazyan B, Yang Z, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH, Pletnikov MV.
Neuropsychopharmacology. 2017; 42:2242-2251.
Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.
Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, Andrabi SA, Pletnikov MV, Pulver AE, Avramopoulos D, Bonci A, Valle D, Dawson TM, Dawson VL.
Sci Transl Med. 2017; 9:eaah4985.
A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia.
Sumitomo A, Horike K, Hirai K, Butcher N, Boot E, Sakurai T, Nucifora FC Jr, Bassett AS, Sawa A, Tomoda T.
Sci Adv. 2018; 4:eaar6637.
Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.
Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, Aneichyk T, Lerch JP, Qiu LR, Rodriguiz RM, Henkelman RM, Talkowski ME, Wetsel WC, Golzio C, Katsanis N.
Hum Mol Genet. 2019; 28:1474-1486.
Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia.
Koh MT, Shao Y, Rosenzweig-Lipson S, Gallagher M.
Schizophr Res. 2019; 193:119-125.
The glutathione cycle shapes synaptic glutamate activity.
Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A.
Proc Natl Acad Sci USA. 2019; 116:2701-2706.
JHU-083 selectively blocks glutaminase activity in brain CD11 cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A.
Neuropsychopharmacology. 2019; 44:683-694s.
Adolescent Δ9-THC exposure and astrocyte-specific genetic vulnerability converge on NF-κB-COX-2 signaling to impair memory in adulthood.
Jouroukhin Y, Zhu X, Shevelkin AV, Hasegawa Y, Abazyan B, Saito A, Pevsner J, Kamiya A, Pletnikov MV.
Biol Psychiatry. 2019; 85:891-903.
Host-parasite interaction associated with major mental illness.
Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M, Choi EY, Chang DJ, Chen Y, Velivela SD, Leister F, Wood J, Chowdari K, Ducci F, Caycedo DA, Heinz E, Newman ER, Cascella N, Mortensen PB, Zandi PP, Dickerson F, Nimgaonkar V, Goldman D, Harrison PJ, Yolken RH, Sawa A.
Mol Psychiatry. 2020; 25:194-205.
Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.
Khambadkone SG, Cordner ZA, Dickerson F, Severance EG, Prandovszky E, Pletnikov M, Xiao J, Li Y, Boersma GJ, Talbot CC Jr, Campbell WW, Wright CS, Siple CE, Moran TH, Tamashiro KL, Yolken RH.
Mol Psychiatry. 2020; 25: 560-571.
A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia.
Coughlin J, Yang K, Tanaka T, Marsman A, Pradhan S, Wang AM, Ward RE, Bonekamp S, Ambinder EB, Higgs CP, Kim PK, Edwards JA, Varvaris M, Wang H, Posporelis S, Ma S, Tsujimura T, Edden RAE, Pomper MG, Sedlak T, Fournier M, Schretlen DJ, Cascella NG, Barker PB, Sawa A
Mol. Psychiatry. 2020; [Epub ahead of print].
PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N.
Nature Commun. 2020; 11: 5903
From population to neuron: exploring common mediators for 3 metabolic problems and mental illnesses
Takayanagi Y, Ishizuka K, Laursen T, Yukitake H, Yang K, Cascella N, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White M, Eaton W, Mortensen P, Sakurai T, Sawa A
Mol Psychiatry 2020; [Epub ahead of print]
Representative review articles (2012 – present):
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon NJ, Sawa A
Nat Rev Neurosci. 2011; 12:707-22.
Mouse models of gene-environment interactions in schizophrenia.
Kannan G, Sawa A, Pletnikov MV
Neurobiol Dis. 2013; 57:5-11.
Molecular substrates of schizophrenia: homeostatic signaling to connectivity.
Landek-Salgado MA, Faust TE, Sawa A.
Mol Psychiatry. 2016; 21:10-28.
DISC1 a key molecular lead in psychiatry and neurodevelopment: No-more misrupted-in-schizophrenia 1.
Niwa M, Cash-Padgett T, Kubo KI, Saito A, Ishii K, Sumitomo A, Taniguchi Y, Ishizuka K, Jaaro-Peled H, Tomoda T, Nakajima K, Sawa A, Kamiya A.
Mol Psychiatry. 2016; 21:1488-1489.
The continuum of causality in human genetic disorders.
Katsanis N.
Genome Biol. 2016; 17:233.
Toxoplasma gondii: Biological parameters of the connection to schizophrenia.
Xiao J, Prandovszky E, Kannan G, Pletnikov MV, Dickerson F, Severance EG, Yolken RH.
Schizophr Bull. 2018; 44:983-992.
